Salvia Extract Tanshinone IIA is derived from phenanthrene-quinone, which can be isolated from Salvia miltiorrhiza BUNGE. The compound can promote anti-inflammatory, anti-oxidative, and cytotoxic activity, and well as induce apoptosis. Tanshinone IIA has been shown to decrease levels of iNOS and inhibit synthesis of TNF-α, nitric oxide, and IL-1β. Research has indicated that Tanshinone IIA can inhibit the migration of human aortic smooth muscle cells (HASMC) and AP-1 DNA-binding. NF-α-stimulated brain microvascular endothelial cells (BMVECs) studies have supporting evidence that Tanshinone IIA can inhibit the activation of nuclear factor-κ B (NF-κB) and ROS generation.
Basic Information of Salvia Extract
- Name : Salvia Root Extract Tanshinone IIA
- Source: Salvia miltiorrhiza root
- Botanical Name : Salvia miltiorrhiza Bge.
- Spec : 5 to 1, 10 to 1, 20% Tanshinone IIA
- CAS No.:568-72-9
- Appearance: Fine Dark reddish-brown powder
- Country of origin: P.R. China
The Source:
Salvia miltiorrhiza (Dan Shen), also known as red sage, Chinese sage, tan shen, or danshen, is a perennial plant in the genus Salvia, highly valued for its roots in traditional Chinese medicine. Native to China and Japan, it grows at 90 to 1,200 m (300 to 3,940 ft) elevation, preferring grassy places in forests, hillsides, and along stream banks. The specific epithet miltiorrhiza means "red ochre root".
S. miltiorrhiza is a deciduous perennial with branching stems that are 30 to 60 cm (0.98 to 1.97 ft) tall, with widely spaced leaves that are both simple and divided. The .3 m (0.98 ft) inflorescences are covered with hairs and sticky glands. Flowers grow in whorls, with light purple to lavender blue corollas that are approximately 2.5 cm (0.082 ft) long, with a dark purple calyx. Salvia miltiorrhiza prefers well draining soil, with about half a day of sunlight. It is hardy to approximately −10 °C (14 °F).[3] Most Salvia seeds have a higher germination rate when exposed to light, though it is not required.
Main bio-actives
Salvia miltiorrhiza mainly contains phenolic acids and diterpenoids.However ,the main active constituents of salvia are diterpene quinones, known as tanshinones.The tanshinones are unique chemical constituents, and similar compounds are not found in other Chinese herbs.
Tanshinone IIA is one of the most abundant constituents of the root of Salvia miltiorrhiza which exerts antioxidant and anti-inflammatory actions in many experimental disease models in laboratory animals, Tanshinone IIA (Tan IIA) has been widely used for various cardiovascular and cerebrovascular disorders in Asian countries.Tanshinone IIA might be a novel promising therapeutic agent for oxidative stress injury in neurodegenerative diseases.Tanshinone IIA may improve renal dysfunction associated with chronic kidney disease.Tan IIA was effective for attenuating the extent of brain edema formation in response to ischemia injury in rats.Tanshinone IIA has been identified as a natural monoacylglycerol lipase (MAGL) inhibitor with an IC50 value of 48 nM. This has potential for the treatment of cardiovascular diseases and may be a good candidate for the treatment of Alzheimer's disease or other MAGL-associated diseases.
Functions
- Salvia Miltiorrhiza Extract Powder has the Effective for the acne and comedo.
- Salvia Miltiorrhiza Extract Powder with the treatment of hepatitis and lepra disease.
- Salvia Miltiorrhiza Extract Powder has the usage of Anti-infection and anti-inflammatory.
- Salvia Miltiorrhiza Extract Powder is used to cure the coronary heart disease, to improve the coronary artery circulation.
Product Applications
- Applied in pharmaceutical field, salvia miltiorrhiza extract powder is mainly used as Raw Material for clearing heat, anti-inflammation, detumescence and so on.
- Applied in health industry, salvia miltiorrhiza extract powder is mainly used raw material of product for benefiting stomach, increasing energy and boosting the immunity.
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